Pathway Development and Evaluation

Enabling rapid development of bioproducts

We are developing metabolic engineering strategies to enable production targets associated with various beachhead molecules, which are metabolic intermediates that can be converted into several bioproducts, as shown below. 

This map represents a compilation of metabolic pathways that have been described for conversion of biomass-derived carbohydrates to industrial chemicals. Adapted by permission from Springer Nature Customer Service Centre GmbH: Nature, Nature Catalysis, A comprehensive metabolic map for production of bio-based chemicals, Lee, S.Y., et al., © 2019. View a full-size PDF here.

The development of a strain for producing a target associated with a beachhead will enable rapid development of related bioproducts. Similar theoretical yields and processing parameters will enable techno-economic and life cycle assessment of a single exemplar target product to represent each beachhead.

Learn more about how this capability can be leveraged towards your own products of interest in this video.

Potential partners interested in a given target can leverage our metabolic engineering and process scale-up strategies and techno-economic analysis/life cycle analysis capabilities for a related molecule associated with the same beachhead to inform their own strain and bioprocess development. Rather than starting from scratch, partners can leverage our pathway development and evaluation capability as a jumping off point to focus on their own products and processes.

Our pathway development and evaluation is precompetitive research & development that serves as an infrastructure investment to reduce the timeline of bioprocess scale-up for a wide range of potential products. 

Labs: 

  • Argonne National Laboratory
  • Los Alamos National Laboratory
  • Lawrence Berkeley National Laboratory
  • National Renewable Energy Laboratory
  • Oak Ridge National Laboratory
  • Pacific Northwest National Laboratory
  • Sandia National Laboratories